Anti-Aquaporin 2/FITC Conjugated抗体
产品名称： Anti-Aquaporin 2/FITC Conjugated抗体
英文名称： Anti-Aquaporin 2/FITC
产品编号： YB--0261R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
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Anti-Aquaporin 2/FITC Conjugated抗体
| 产品编号 | YB-0261R-FITC |
| 英文名称 | Anti-Aquaporin 2/FITC |
| 中文名称 | FITC标记的水通道蛋白-2抗体 |
| 别 名 | ADH water channel; AQP 2; AQP-2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AQP2 (101-150aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus. Function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Subcellular Location: Apical cell membrane. Cytoplasmic vesicle membrane. Shuttles from vesicles to the apical membrane. Tissue Specificity: Expressed in renal collecting tubules. Post-translational modifications: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. DISEASE: Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive. Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. Database links: Entrez Gene: 359 Human Entrez Gene: 11827 Mouse Entrez Gene: 25386 Rat Omim: 107777 Human SwissProt: P41181 Human SwissProt: P56402 Mouse SwissProt: P34080 Rat Unigene: 130730 Human Unigene: 20206 Mouse Unigene: 90076 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 通道蛋白（Channel Protein） 水通道蛋白-2特异地存在于肾脏集合管，受血管加压素调节。有研究证明，AQP2(水通道蛋白-2)在糖尿病肾脏集合管表达增强. 在1型糖尿病动物模型的水转运中尤其有意义。研究认为：AQP-2 奠定了糖尿病大鼠肾脏对水重吸收的基础，而且发现1型糖尿病病人的 AQP-2随血糖控制而减少 |