FITC标记的富含半胱氨酸蛋白2抗体
产品名称： FITC标记的富含半胱氨酸蛋白2抗体
英文名称： Anti-CSRP2/FITC
产品编号： HZ-12946R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CSRP2/FITC Conjugated antibody
FITC标记的富含半胱氨酸蛋白2抗体
| 英文名称 | Anti-CSRP2BP/FITC |
| 中文名称 | FITC标记的富含半胱氨酸蛋白结合蛋白抗体 |
| 别 名 | ADA2A containing complex subunit 2; ADA2A-containing complex subunit 2; ATAC2; CRP2 binding partner; CRP2-binding partner; CRP2BP; CSR2B_HUMAN; CSRP2 binding protein; CSRP2-binding protein; Csrp2bp; Cysteine rich protein 2 binding protein; Cysteine-rich protein 2-binding protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 信号转导 转运蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 89kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CSRP2BP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CRP2BP is a 782 amino acid protein encoded by the human gene CSRP2BP. CRP2BP specifically interacts with the double LIM domain protein CRP2. The LIM domain is a conserved cysteine and histidine-containing structural module of two tandemly arranged zinc fingers. It has been identified in single or multiple copies in a variety of regulatory proteins, either in combination with defined functional domains, like homeodomains, or alone, like in the CRP family of LIM proteins. Members of the cysteine- and glycine-rich protein family (CRP1, CRP2 and CRP3) contain two zinc-binding LIM domains, LIM1 (amino-terminal) and LIM2 (carboxyl-terminal), and are implicated in diverse cellular processes linked to differentiation, growth control and pathogenesis. Although present in cytoplasm, CRP2BP is mainly a ubiquitously expressed nuclear protein, with highest expression in skeletal muscle and heart. Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. Subunit: Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5. Subcellular Location: Nucleus. Cytoplasm. Mainly nuclear. Tissue Specificity: Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung. Similarity: Contains 1 N-acetyltransferase domain. Database links: Entrez Gene: 57325 Human Entrez Gene: 228714 Mouse SwissProt: Q9H8E8 Human SwissProt: Q8CID0 Mouse Unigene: 488051 Human Unigene: 728790 Human Unigene: 227925 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
CRP2是一个193个氨基酸的核蛋白，属于LIM结构域蛋白的CRP家族。在主动脉平滑肌细胞中高表达，CRP2被认为已经在胚胎血管系统发育的作用与下调后细胞损伤或PDGF-B曝光。CRP2包含两个LIM锌结合域是由一个基因映射到人类染色体12编码，编码超过1100基因包括人类基因组约为4.5%.。12号染色体与多种疾病和疼痛有关，包括软骨发育不良、软骨发育不全、Kniest。