EXOSC2抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
EXOSC2抗体

EXOSC2抗体

商家询价

产品名称： EXOSC2抗体

英文名称： EXOSC2Antibody

产品编号： XY14805-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 EXOSC2抗体

Applications
In-house applications ELISA, WB, IHC, IF, IP     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev12NextView more validation data
  • 14805-1-AP;HeLa cellsHeLa cells were subjected to SDS PAGE followed by western blot with 14805-1-AP(EXOSC2 antibody) at dilution of 1:500
  • 14805-1-AP;human skin cancerImmunohistochemical of paraffin-embedded human skin cancer using 14805-1-AP(EXOSC2 antibody) at dilution of 1:100 (under 40x lens)
  • 14805-1-AP;MCF-7Immunofluorescent analysis of MCF-7 cells, using EXOSC2 antibody 14805-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
  • 14805-1-AP;HeLa cellsIP Result of anti-EXOSC2 (IP:14805-1-AP, 4ug; Detection:14805-1-AP 1:1000) with HeLa cells lysate 1080ug.
Positive WB detected in HeLa cells, HepG2 cells, Jurkat cells, MCF7 cells
Positive IP detected in HeLa cells
Positive IHC detected in Human skin cancer tissue
Positive IF detected in MCF-7 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:20-1:200
 EXOSC2抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen EXOSC2 fusion protein ag6525 Full name Exosome component 2
Calculated molecular
weight		 33 kDa Observed molecular 
weight		 30-33 kDa
GenBank accession 
number		 BC000747 Gene ID (NCBI) 23404
Gene symbol EXOSC2 Synonyms EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p
Background EXOSC2抗体

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563]. EXOSC2抗体

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