CHD1抗体
Applications
| Tested Applications: |
ELISA, WB, IHC, IP |
| Cited applications |
IF, WB |
| Specificity Reaction: |
Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology |
| Cited species |
Mouse |
| Positive WB detected in |
HeLa cells, A431 cells, human brain tissue, Jurkat cells |
| Positive IP detected in |
HeLa cells |
| Positive IHC detected in |
Human breast cancer tissue |
| Recommended dilution |
WB : 1:500-1:5000
IP : 1:200-1:1000
IHC : 1:20-1:200 |
CHD1抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
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HeLa cells were subjected to SDS PAGE followed by western blot with 20576-1-AP(CHD1 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human breast cancer using 20576-1-AP(CHD1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human breast cancer using 20576-1-AP(CHD1 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-CHD1 (IP:20576-1-AP, 4ug; Detection:20576-1-AP 1:300) with HeLa cells lysate 1600ug.
Product Information
| Source: |
Rabbit |
Purify: |
Antigen affinity purification |
| IsoType: |
IgG |
Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: |
Peptide |
Full Name: |
Chromodomain helicase DNA binding protein 1 |
Caculated Molecular
Weight: |
197 kDa |
Observed Molecular
Weight: |
200 kDa |
| GenbankNo |
NM_001270 |
GeneID: |
1105 |
| Symbol |
CHD1 |
Synonyms |
ATP dependent helicase CHD1, CHD 1, CHD1, DKFZp686E2337 |
Background CHD1抗体
|
CHD1 belongs to the SNF2/RAD54 helicase family. CHD1 is an aTP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. CHD1 regulates polymerase II transcription. It is required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. CHD1 regulates negatively DNA replication. It is required to maintain a specific chromatin configuration across the genome. It is associated with histone deacetylase (HDAC) CHD1抗体 activity. CHD1 is required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. It functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. It is required for maintaining open chromatin and pluripotency in embryonic stem cells. The antibody is specific to CHD1.
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