随着生命科学的不断发展及对单细胞分析手段越来越高的需求,传统的荧光流式细胞技术已不能满足科学家们的需要。Fluidigm公司独有的质谱流式技术（Mass Cytometry）应运而生。它通过对传统流式技术和质谱技术的整合，是目前单细胞多参数分析中最先进的技术之一。它继承了传统流式细胞仪的高速分析的特点，又具有质谱检测的高分辨能力，更高效、更易用，同时能够更加深入地进行细胞表型、信号通路和功能的全面研究，是流式细胞技术一个新的发展方向。
|
标题 |
刊物 |
发表时间 |
研究内容 |
|
High Dimensional Mass Cytometry Analysis Reveals Characteristics of the Immunosuppressive Microenvironment in Diffuse Astrocytomas |
Frontiers in Oncology |
Feb, 2020 |
弥漫性星形细胞瘤(DA)的免疫微环境特征研究 |
|
A Carrier Strategy for Mass Cytometry Analysis of Small Numbers of Cells |
Methods Mol Biol |
Jan, 2020 |
Cytof技术检测方法研究 |
|
Phenotype molding of T cells in colorectal cancer by single-cell analysis |
Int J Cancer |
Jan, 2020 |
研究大肠癌中T细胞表型变化 |
|
A comparison framework and guideline of clustering methods for mass cytometry data |
Genome Biol |
Dec, 2019 |
质谱流式数据聚类分析方法比较 |
|
High-dimensional single-cell proteomics analysis reveals the landscape of immune cells and stem-like cells in renal tumors. |
J Clin Lab Anal |
Dec, 2019 |
不同类型肾肿瘤免疫细胞亚群分析 |
|
A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation. |
Blood Adv |
Dec, 2019 |
脐带血移植恢复期，NK细胞多样性及其对随后复发的风险预测 |
|
Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells |
Exp Cell Res. |
Nov, 2019 |
CyTOF在胃癌研究中的应用价值 |
|
Glutathione Might Attenuate Cadmium-Induced Liver Oxidative Stress and Hepatic Stellate Cell Activation |
Biol Trace Elem Res. |
Oct, 2019 |
镉诱导的肝氧化应激和肝星状细胞活化 |
|
Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. |
Cell Mol Immunol |
Oct, 2019 |
研究IL-38在过敏性哮*中的抗炎机制 |
|
Single-cell mass cytometry reveals in vivo immunological response to surgical biomaterials |
Applied Materials |
Sep, 2019 |
应用质谱流式技术研究生物材料植入对免疫系统的影响 |
|
A Mass-Ratiometry-Based CD45 Barcoding Method for Mass Cytometry Detection |
SLAS Technol |
Aug, 2019 |
Cytof细胞Barcode方法研究 |
|
Immunomodulatory effect of mesenchymal stem cells in chemical-induced liver injury: a high-dimensional analysis |
Stem Cell Res Ther. |
Aug, 2019 |
MSCs肝损伤过程中的免疫调节作用 |
|
The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer. |
Int J Radiat Oncol Biol Phys. |
Aug, 2019 |
RhoB信号通路与结直肠癌耐受放疗机制研究 |
|
Immunocyte Profiling Using Single-Cell Mass Cytometry Reveals EpCAM+ CD4+ T Cells Abnormal in Colon Cancer |
Front Immunol. |
Jul, 2019 |
研究结直肠癌患者PBMC的表型变化和免疫治疗靶点的表达 |
|
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas |
Gut |
Jun, 2019 |
多组学HCC免疫微环境研究 |
|
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1 |
Gastroenterology. |
May, 2019 |
小鼠肝肿瘤对MET抑制剂耐药机制研究 |
|
Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis. |
JCI Insight |
Mar, 2019 |
银屑病患者PBMC的免疫细胞亚群和信号通路分析 |
|
Reduced CD27-IgD- B Cells in Blood and Raised CD27-IgD- B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease. |
Front Immunol. |
Mar, 2019 |
研究炎症性肠病（IBD）的肠内B细胞募集 |
|
Ratiometric Barcoding for Mass Cytometry. |
Anal Chem. |
Sep, 2018 |
质谱流式技术barcoding方法 |
|
Octaarginine-modified gold nanoparticles enhance the radiosensitivity of human colorectal cancer cell line LS180 to megavoltage radiation. |
Int J Nanomedicine. |
Jun, 2018 |
纳米材料促进结直肠癌细胞系放射敏感度机制研究 |
|
Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia |
J Transl Med |
Feb, 2018 |
阿帕替尼抗白血病机制研究 |
|
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. |
Nat Immunol. |
Jul, 2017 |
TAZ在 TH17和Treg分化过程中的作用 |
|
Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer. |
Mol Cancer. |
Mar, 2017 |
PXR对奥沙利铂的转运作用及其引发的耐药性机制研究 |
|
Single cell proteomics in biomedicine: High-dimensional data acquisition, visualization, and analysis. |
Proteomics. |
Feb, 2017 |
数据分析方法研究 |